Virginia was overwhelmed from the outset on the road, falling behind 21-7 after first quarter and trailing 35-7 at the half.
The Cavaliers' defense was helpless against the Yellow Jackets option. Paul Johnson's team ran all over Virginia, amassing 470 yards on 48 attempts.
Running back Orwin Smith seemed unstoppable, gaining 137 yards on just six carries while scoring once on a 77-yard touchdown foray.
Tevin Washington was superb as well, throwing for 125 yards and a touchdown while rushing for 93 yards and scoring three more times.
Offensively, the Cavaliers weren't much more successful. Michael Rocco was average, completing 16-of-26 for 147 yards while throwing for one touchdown and two interceptions.
It was a tough loss for Virginia in its ACC opener after winning its first two games against the Richmond Spiders and Penn State Nittany Lions.