The Redskins are 2-3 and coming off of a tough loss to the unbeaten Atlanta Falcons while Minnesota continues to roll at 4-1, beating the Tennessee Titans last weekend for their third consecutive victory.
Washington hopes to have Robert Griffin III back, after he suffered a concussion in the third quarter against the Falcons.
Around the league, there are plenty of good games to keep an eye on.
The Detroit Lions travel to play the Philadelphia Eagles in a battle of two NFC powers. Both have been inconsistent this year, with the Lions shocking many experts at 1-3. Philadelphia is 3-2, but still looks like a team that struggles to put good games together.
Perhaps the best contest this weekend will take place on the East Bay, with a re-match of the NFC Championship game. The San Francisco 49ers are hosting the New York Giants, looking to exact a small measure of revenge. The Niners have been dominant the past two weeks, beating the New York Jets and Buffalo Bills by a combined 79-3 margin.