Fans will likely focus on the first NFL showdown between Andrew Luck and Robert Griffin III, who were selected first and second in 2012's NFL draft. The Redskins are commemorating the head-to-head battle with t-shirts.
Redskins RB TIm Hightower, returning from reconstructive knee surgery, will reportedly make his 2012 debut. It will be a timely return for Hightower, as RBs Roy Helu Jr. and Evan Royster will both miss Saturday's game with injuries of their own.
Colts WR Austin Collie is not expected to play after suffering yet another concussion in last week's game.
Saturday's game will kick off at 4:00 PM EDT and can be viewed on the NFL network.